Stability of pharmaceutical products can be defined as the ability of a product to survive within the specified limit throughout the period of storage and use, the characteristics and characteristics are the same as those they have when they are made. Compounding medicine is an important part of pharmaceutical services that must ensure the safety and quality of the preparation ingredients. In 2016 the finding of cases of pneumonia under five in Purbalingga Regency was 1,341 cases and in 2017 the findings of pneumonia cases of children under five had increased by 1,508 cases. The aim of this study was to determine the physical stability and microbial contamination of preparations for the concoction of pneumonia drug pulveres at the Purbalingga District Health Center. This type of research is non-experimental with a survey approach. Based on the survey, the health center that fulfilled the criteria are Bobotsari Health Center, Mrebet Health Center, Bojongsari Health Center, Kutasari Health Center, Pengadegan Health Center, and Kejobong Health Center with the highest prescription percentage of 51.40% for Ambroxol, Dexamethasone and Salbutamol. The microbiological acceptance criteria permitted on non-sterile preparations for non-aqueous oral use are 103 CFU/g or CFU/ml aerobic microbial total and fungal / mold total 102 CFU/g or CFU/ml. The results showed that the physical stability of the Bobotsari Health Center and Kutasari Health Center decreased in the second week based on the organoleptic test. Whereas The results of microbial contamination showed that the preparation of pneumonia drug pulveres in the Pengadegan Health Center was declared not fulfilling the microbiological quality requirements for bacteria and the Kejobong Health Center was declared not to meet the microbiological quality requirements for bacteria and fungi.