The objective of this study was to describe strategies in learning vocabulary that were most frequently used by second semester students of English Education Department Muhammadiyah University of Purwokerto in academic year 2017/2018. The data was taken in August 2017 at English Education Department Muhammadiyah University of Purwokerto. This study used descriptive quantitative study. In collecting data the writer used a questionnaire as an instrument which consisted 25 items adapted from Schmitt’s (1997) taxonomy of vocabulary learning strategies. The writer decided the sample by using purposive sampling. The total number of samples was 79 respondents of second semester students who were studying in English Education Department Muhammadiyah University of Purwokerto in academic year 2017/2018. The writer analyzed the data by using percentage to decide the strategies in learning vocabulary most frequently used by the respondents. The results of the research finding were: determination strategies (59.1%), social strategies (59.6%), memory strategies (61.7%), cognitive strategies (60.6%), and metacognitive strategies (65.8%). The score result indicated that the use of metacognitive strategy was the most used by second semester students of English Education Department Muhammadiyah University of Purwokerto in academic year 2017/2018. The students most frequently used the metacognitive strategies in learning vocabulary.