Background: Pain is one of the signs that there is a dysfunction or damage to the
body's organs. Sambiloto (Andrographis paniculata, Nees) is known to have
pharmacological effects, one of which is analgesics. Andrographolide compounds
are believed to be the trigger for analgesic effects, from the solubility of
andrographolides which are relatively insoluble in water, have the potential to be
used as pharmaceutical preparations by formulating them into cream preparations.
In the formulation of sambiloto extract cream, stearic acid and triethanolamine are
surfactants. Methods: Standardization of sambiloto extract was done by looking at
specific and nonspecific parameters. Using the simplex lattice design method, 8 run
formulas were obtained. Then organoleptics, homogeneity, pH, viscosity,
dispersion and adhesion tests are carried out to determine the optimal formula.
Results: The results of standardization of sambiloto extract showed a form in the
form of a thick extract, dark brown color, distinctive smell of sambiloto, very bitter
taste, % yield of 9.8743%, moisture content of 5.8598%, total ash content of
1.8958%, acid insoluble ash content of 0.4410% and chemical content of the extract
of 25.1307%. The optimum formula of sambiloto extract cream has a proportion of
stearic acid of 18% and triethanolamine of 3% with a desirability value of 0.997.
The verification results showed a pH result of 6.37; viscosity 16,550 cPs; spread
power 5.77 cm; adhesion of 4.67 seconds which does not differ significantly and is
stable regarding organoleptics, pH, dispersion and adhesion. Conclusion: The
cream optimization of sambiloto extract has a proportion of stearic acid of 18% and
triethanolamine of 3%. The ratio of these combinations affects the response of its
physical properties. The optimum formula of sambiloto extract cream is stable at
extreme temperatures and has pH, viscosity, spread, and adhesion values according
to good cream parameters.