Background: Analgesic drugs used inappropriately and excessively can have adverse effects on their users. Sambiloto leaf patch preparations have the potential to be analgesic candidates with the main content of andrographolide which contains diterpene lactone compounds as the active ingredient of analgesic drugs. The combination of hydrophilic and hydrophobic polymers is a composition that plays an active role in improving the physical and mechanical properties of good patch preparations. Methods: Standardization of chemical content of sambiloto leaf extract and polymer optimization in patch formula using Simplex Lattice Design with tensile strength, elongation at break, and modulus young as optimization parameters. Then a physical test is carried out as an additional parameter. Results: The chemical content of sambiloto leaf extract was obtained at 71.1798 ± 12.9184. The optimal formula of PVP 100 mg and EC 1900 mg was obtained with a desirability value of 0.843. The tensile value was 1.15-2.84 N/mm^2, the elongation at break was 175.85-191.59%, and the modulus young was 0.83-1.49 mPa. Physical and mechanical properties tests on all optimum formulas are qualified. Conclusion: The most dominant polymer gives the optimal response, namely PVP at the elongation value at break and modulus young, then EC at the tensile value of strength.