This study aims to determine the effect of perceived convenience, perceived usefulness, trustworthiness, service quality on the use of accounting information systems. The sampling technique in this study used non-probability sampling with the accidental sampling method. The sample in this study were Tokopedia e-commerce users in Banyumas Regency. Data analysis used Structural Equation Modeling (SEM) with Partial Least Square (PLS) approach with the help of SmartPls v.3.3.6 program. The results showed that perceived usefulness, trustworthiness, and service quality had an effect on users of accounting information systems. Perception of ease has no effect on users of accounting information systems.