Dengue Hemorrhagic Fever (DHF) is a disease caused by dengue virus that is transmitted through the bite of the Aedes aegypti mosquito as the main vector. Tembelekan (Lantana camara L.) is used as an ornamental plant in Indonesia.Tembelekan plant in India was reported that it had activity against several mosquito larvae. The Chemical content that is suspected to have larvicidal activity are flavonoids, cardiac glycosides, saponins, triterpenoids and essential oils. Based on these, the researcher would like to test the larvicidal activity of Tembelekan leaves in Indonesia. In this research, the activity of larvicidal were tested on four kinds of extracts, there are n-hexane extract, ethyl acetate, ethanol and infusion extracts on A.aegypti mosquito larvae so that the extract with the best larvicidal activity was obtained. Method: A. aegypti larvicide activity test on the Tembelekan leaves was carried out using 20 larvae for one test. There are 3 treatments, those are positive control (abate 1%), negative control (aquadest), and extract of n-hexane, ethyl acetate, ethanol and Tembelekan leaf infusion treatment. The observed data is the number of dead larvae for 24 hours. Furthermore, those are identified the compound group by using Thin Layer Chromatography (TLC). Results: The results of this research show that there are differences between each test sample. The LC50 value of n-hexane extract was 0.406 g/mL, the LC50 value of ethyl acetate extract was 0.049 g/mL, the LC50 value of ethanol extract was 0.108 g/mL, and the LC50 value of Tembelekan infusion was 32.200 g/mL. Conclusion: Based on the results of the research, it can be concluded that the extracts of n-hexane, ethyl acetate, ethanol and infusion of Tembelekan leaves have larvicidal activity against Aedes aegypti larvae. Ethyl acetate extract was the most effective as larvicide with an LC50 value of 0.049 g/mL.