Uric acid is derived from the degradation of purines nucleotides which are the end product of purine catabolism that occurs in all cells. This study aims to find out the effect of ethanol extract mangosteen peel (Garcinia mangostana L.) on the decrease in uric acid levels of wistar strain rats, make granule extract preparations and calculate xanthone levels in granule preparations. Method: Antihyperuricemia activity test was conducted on wistar strain mice divided into 4 groups, they are negative, positive group (allopurinol 9mg / kgBB), dose group of 40 mg/ kgBB, and dose group of 80 mg/kgBB, making granule extract preparations and calculating xanthone levels in granule preparations. Results: In the mangosteen peel extract group doses of 40 mg/kgBB and 80 mg/kgBB can reduce uric acid on days 1, 7, and 14. In determining the total xanthone levels of granules of mangosteen peel ethanol extract obtained a result of 4.024 mg in 50 mangosteen peel extracts and 3.905 mg in granules equivalent to 50 mg extract. Conclusion: Mangosteen peel extract can lower the uric acid levels of rats at doses of 40mg/kgBB and 80 mg/kgBB, obtained granules that qualify for the physical test of granules, and the granulation process affects the decrease in total xanthone levels.