The 2013 curriculum has a goal to shape Indonesian people who are productive, creative, innovative, through strengthening integrated attitudes, knowledge, and skills. To build people who are productive, creative, innovative, and have knowledge and skills, an innovation in learning is needed by combining two skills, namely science and entrepreneurship. Sainspreneur is an ability to manage science and science skills to be utilized and improved so that it is more optimal (good) so that it can improve the standard of living in the future. Science learning is combined with entrepreneurial education or what is called a sainspreneur. The application of Sainspreneur is STEAM-oriented with five learning stages, namely: the information-gathering stage, the innovation stage, the production stage, the application stage, and the evaluation stage. Its application is through urban farming, namely the strategy of using yards as a family food defense that has economic value. Equipping the life skills of students at SD Muhammadiyah Banjarnegara District with the application of entrepreneurial sciencefor develop independence and creativity. This type of research is a true-experimental post-test only group design with the research sample being the fourth grade students of SD Muhammadiyah Banjarnegara sub-district. Looking at the results of the questionnaire hypothesis test to measure independence by the researcher, with a 2-tailed probability (significance) value of 0.000 < 0.05, H1 is accepted, it can be concluded that there is an effect of the application of sainspreneur on science learning independence for fourth grade students of SD Muhammadiyah 2 Banjarnegara. Looking at the results of the post-test hypothesis test to measure creativity by the researcher, with a 2-tailed probability (significance) value of 0.000 < 0.05, then H1 is accepted. So it can be concluded that there is an effect of applying entrepreneur science to the creativity of fourth grade students at SD Muhammadiyah 2 Banjarnegara.