This research aims to find the effect of variable reseacrhed which are brand image, brand extension and after-sales service on purchase decision of Oppo handphone in the Faculty of Economics and Business University Muhammadiyah Purwokerto. This research used quantitative research method. Non-probability sampling technique, with purposive sampling method was used to got the sample based on certain criteria. The population in this study is the buyer of Oppo handphone the Faculty of Economics and Business of University Muhammadiyah Purwokerto. The sample of this research is 100 respondents. The research method used in this research are validity test, reliability test, classical assumption test, multiple regression analysis, coefficient of determination, and hypothesis test. The analysis results showed that brand image and after-sales service have a positive and signifficant effect on purchasing decision. Brand extension has a positive but not significant effect on purchasing decisions. Then, analysis results showed that brand image, brand extension and after-sales service effect simultaneously on purchasing decision. While the effect of the variability of all variables on the purchase decision were 67.1%.