The purpose of this study was to analysis of the influence of perception of usefulness, perception of easy, perception of system security, and service quality on accounting information system use on the use of shopee e-commerce in banyumas and cilacap regencies. Data collection techniques through questionnaires. The sampling technique used non-probability sampling with the accidental sampling method with a total sample of 156 respondents who met the criteria. Analysis of the study using Structural Equation Modeling (SEM) approach Partial Least Square (PLS). The results showed that perceived usefulness and service quality had a positive effect on the use of accounting information systems. Another result is the ease and perception of the security system has no effect on the use of accounting information systems.