Dengue Hemorrhagic Fever (DHF) is a disease that is spread
through the bite of Aedes aegypti mosquitoes. Beginning in 2016, Banjarnegara
District has experienced an outbreak of DHF with an increase in the number of
DHF cases by 230 cases until the first week of April 2016. Chemical compounds
contained in karika leaves are flavonoids, alkaloids, tannins, saponins, and
phenols. In this study, tested on several samples, namely n-hexane extract, ethyl
acetate extract, ethanol extract and karika leaf infusion to determine which is the
most effective cause of death of A. aegypti larvae. Method: A. aegypti larvaside
activity test against karika (C. pubescens) leaves was carried out using larvae
which were divided into several groups, namely positive control group (abate 1%),
negative control (aquades), DMSO control, n-extract extract, ethyl acetate extract,
ethanol extract and the karica leaf infusion treatment group. The observed data is
the number of larval deaths within 24 hours. In addition, the qualitative and
quantitative identification of compounds was tested using Thin Layer
Chromatography (TLC) - Densitometry. Results: The results showed that all
samples had larvicidal activity against A. aegypti larvae. The LC50 value of nhexane
extract was 2.653 g / mL, ethyl acetate extract was 1.832 g / mL, ethyl
acetate extract was 3.185 g / mL, and the LC50 value of karica leaf infusion was
8.551 g / mL. Conclusion: Based on the results of the study it can be concluded
that the extracts of n-hexane, ethyl acetate extract, ethanol extract and infusion of
karika leaves have larvicidal activity against A. aegypti larvae. Ethyl acetate
extract was the most effective as larvicide compared to other samples with LC50
value of 1,832 g / mL.