Tuberculosis (TB) is a contagious disease that remained a global health problem.In 2015, the total number of TB cases in Banyumas regency was 1126 cases, with cases of 0-14 years child TB was 4.97% and the death rate during treatment was 0.70 per 100,000 population. As many as 30%-50% of cases of patient non-compliance behavior in receiving drugs are due to lack of education related with therapy, and pharmacist can provide counseling as a solution.This study aims to determine the comparison of influence of pharmacist counseling to the level of caregiver knowledge of pediatric pulmonary tuberculosis patients in GHS and NGHS of Banyumas Regency. The method of this research is observational analytic study with cross sectional design and the data collection method is accidental sampling in GHS and NGHS of Banyumas Regency. There was 29 caregivers as research population, with 14 (48.27%) as GHS respondents, and 15 (51.73%) as NGHS respondents. To find out the level of respondent's knowledge, used pretest-posttest questionnaires.The data research of knowledge level analyzed by using Wilcoxon test obtained by Asymp.Sig value 0,013 (p<0,05) at GHS and Asymp.Sig value 0,013 (p<0,05) at NGHS so it could be concluded that there were significant differences in the level of respondent’s knowledge at before and after being given counseling at both health care services.Data from the difference in pre- and post-counseling knowledge levels in GHS and NGHS were compared using the Mann Whitney test and obtained Asymp.Sig values was 0.684 (p>0.05). It could be concluded that pharmacist counseling in two different health care places (GHS and NGHS) has a similar effect to the level of caregiver's knowledge.