method. In another test, the modifications of photosensitizer with addition an amino acid such as arginine, serine and lysine, also 1-hydroxyethyl can enhance the effectiveness of anticancer compounds.
Objective : This study aimed to determine the quantitative relationship of structure and activity of bacteriopheophorbide a derivatives as anticancer, QSAR equation determines the shape of bacteriopheophorbide a derivatives which can be selected and used in the modeling, as well as bacteriopheophorbide a derivative compounds that have anti-cancer activity higher.
Methods : The method of computing using the software ChemDraw, Gaussian, and the Molecular Operating Environment (MOE).
Results : IC50 value obtained prediction is serine bakteriofeoforbid a (0.0000301 ng/mL), 1-hydroxyethyl bakteriofeoforbid a (0.001778 ng/mL), lysine bakteriofeoforbid a (0.005888 ng/mL), arginine bakteriofeoforbid a (0.008892011 ng/mL), and bakteriofeoforbid a (0.012246161 ng/mL). The combination bakteriofeoforbid compounds with amino acids makes this compound more potent in treating cancer. This can be seen from the IC50 values derived bakteriofeoforbid a smaller than the IC50 value bakteriofeoforbid a.
Conclusion : Compounds of derivative bacteriopheophorbide a predicted have potential as anti-cancer better is bacteriopheophorbide a serine compounds with IC50 values 0.0000301 ng/mL.