Covid-19 had a major impact on the health sector, 1,522 people were
recorded as experiencing depression due to the Covid-19 pandemic in Indonesia. It
is estimated that depression will rank as the second deadliest non-communicable
diseases in the world in 2020, so it is necessary to conduct research at the Regional
Mental Hospital in Surakarta. Inaccurate use of antidepressants can aggravated the
patient's condition causing new problems such as death. Therefore, therapeutic
evaluation and identification of ADR (Adverse Drug Reaction) is needed which
aims to determined the description of antidepressant drug use, evaluated the
accuracy of antidepressant use based on therapeutic guidelines and determined the
effectiveness of antidepressant therapy in depressed patients and the magnitude of
the incidence of drug side effects on antidepressant use patterns. Methods: This is
a non-experimental studied, designed descriptively and data collection techniques
were carried out prospectively, supported by secondary data, namely data taken
from medical record cards. The data obtained were analyzed using therapeutic
guidelines, the HAM-D score and the Naranjo Scale. Results: From the study of 30
depressed patients, it was found that the most common antidepressants used were
Fluoxetine 43.33%, then Sertraline 26.66%, Escitalopram 3.33% , Maprotilin
20.00% and Amitriptyline as much as 6.66%. From the evaluation of treatment
accuracy, it was found that 100% correct indication, 96.66% correct patient, 100%
correct drug and 93.33% correct dose. The results of the outcome of antidepressant
therapy were effective in reducing depressive episodes as seen from the mean
HAM-D score <7 and a 50% reduction in symptoms from initial symptoms. And
found 21 study subjects (70%) who had ADR and 30% (9 patients) of study subjects
did not experience ADR.