The purpose of this study was to determine the effect of Return On Asset (ROA), Operational Costs on Operating Income (BOPO), Financing to Deposit Ratio (FDR), Non Performing Financing (NPF), Inflation and BI Rate on the Profit Sharing Rate of Mudharabah Time Deposits at Banks. General Sharia in Indonesia 2015-2019. The population is 14 Islamic commercial banks and a sample of 8 Islamic commercial banks. Based on the criteria, 160 samples were obtained. The data analysis technique used in this research is descriptive statistical test, classical assumption test, multiple linear regression analysis, model accuracy test, partial test and partial test. The results of the analysis show that the Return On Assets (ROA) has a significant negative effect on the profit sharing rate of mudharabah deposits, while the Operational Costs on Operating Income (BOPO) and Non Performing Financing (NPF) have a significant positive effect on the profit sharing rate of mudharabah deposits and Financing to Deposit. Ratio (FDR), inflation, and the BI Rate show that there is no effect on the profit sharing rate of mudharabah deposits.