Fast Disintegrating Tablet ethanol extract of Jamaican Cherry leaves are one of the
strategies for fast disintegrating tablets to overcome swallowing difficulties in some
hypercholesterolemic patients. Superdisintegrants are needed for FDT preparations
to make them disintegrate faster, A vicel PH 102 with a wicking mechanism
combined with SSG as a tablet crusher, so it can reduce tablet disintegration time
quickly. The purpose of this study was to optimize the formula with a combination
of A vicel PH 102 and SSG as a superdisintegrant FDT of ethanol extract of
Jamaican Cherry leaves (Muntingia calabura L.). The optimum formula was
determined by the Simplex Lattice Design (SLD) method in the Design Expert
software with two variables, namely Sodium Starch Glycolate (SSG) and Avicel
PH 102, in order to obtain 8 run formulas. Fast Disintegration Tablet preparations
were made using the wet granulation method. The tablets were tested for physical
properties including organoleptic, weight uniformity, brittleness, hardness, and
disintegration time. The results of SLD analysis using Design Expert software,
obtained the optimum formula, namely Avicel PH 102 of 53.5516 mg and SSG
41.4484 mg, with a desirability value of0.424. Then the combination of Avicel PH
102 and SSG had an effect in reducing the FDT disintegration time of the ethanol
extract of Jamaican Cherry leaves (Muntingia calabura L.).