REVANA, RAISA (2023) FORMULASI DAN UJI AKTIVITAS PENANGKAPAN RADIKAL BEBAS SERUM EKSTRAK BUAH TOMAT (Solanum lycopersicum L.) MENGGUNAKAN METODE DPPH. S1 thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.
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Abstract
Background: Tomato fruit is rich of its potential antioxidant compounds to scavenge free radicals. Skin is the outer organ that oftenly exposed to free radicals. External factors such as polution, vechile emission, chemical substances and ultraviolet rays generate free radicals exposure onto skin therefore resulting development of hyperpigmentation, lessening catalase activity, reducing collagen and skin elasticity. Tomato fruit is potential to overcome the issues by developing it as a cosmetic serum that may simplify the usage and with expected good stability. Objective: To acknowledge whether tomato fruit is eligible for serum formulations with concentration variation of carbopol, DPPH scavenging activities and its stability. Method: Formulation is conducted with trial and error method, radical scavenging activities using DPPH assay, accelerated stability test using freeze-thaw cycling and stored in climatic chamber. Result: The results of free radical scavenging activity test of the three serum formulas have IC50 values of F1 37.70 ppm, F2 45.59 ppm, and F3 53.22 ppm. The results of the accelerated stability test in form of preparation evaluation showed that all serum formulas remained stable after passing the cycling test for 6 cycles and 60 days of storage in the climatic chamber. Conclusion: Results were obtained in conclusion that the three formulas had excellent free radical scavenging activity. The serum formulas showed that the preparation remained stable after the accelerated test by cycling test and storage in the climatic chamber.
| Dosen Pembimbing: | ASTUTI, IKA YUNI and UTAMI, PRI ISWATI | nidn0628067401, nidn0619057601 |
|---|---|
| Item Type: | Thesis (S1) |
| Uncontrolled Keywords: | free radical, tomato fruit, serum |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Farmasi S1 |
| Depositing User: | wulan |
| Date Deposited: | 29 Mar 2023 02:50 |
| Last Modified: | 29 Mar 2023 02:50 |
| URI: | http://repository.ump.ac.id/id/eprint/15417 |
