Background: Lemongrass (Cymbopogon nardus (L.) Rendle) is a plant that has
antibacterial activity especially on Streptococcus mutans so that it can be
formulated into an edible film.. Edible film is one example of mucoadhesive
preparations having the ability to increase residence time on the mucosa better than
oral gel preparations. Method: The Edible films are made of 6 formulas with
HPMC and sorbitol in the same concentration range of 0-3% . The optimization
of the formula was carried out using Software Design Expert version 13 of the
Simplex Lattice Design method with a response to mechanical tests, namely tensile
strength and elongation at break.The formula was evaluated for characteristics of
organoleptic, pH, patch thickness, solubility test and antibacterial test. Result : The
optimum patch formula was obtained at concentrations of HPMC 0,55 %
concentrations of 2,45 % with predicted tensile strength response 0,88 N/nm2 and
elongation at break 50,74% with the obtained desirability value of 0,533. The
antibacterial test it was found that the edible film had a inhibition zone of
17,08±0,71 mm. Conclusion: The combination of HPMC and sorbitol in the edible
film strip preparation has an influence on the physical properties and meets the
quality requirements of the edible film preparation and the antibacterial test shows
that the edible film lemongrass leaf juice has an antibacterial activity against
Streptococcus mutans..