This study aims to examine and analyze the effect of leadership style and job training on employee performance through job satisfaction at Ananda Purwokerto General Hospital (RSU). The population used in this study were all employees of the Ananda Purwokerto General Hospital except doctors, directors and managers. The sample of this research was 105 employees with the sampling technique using the techniquequota sampling with the proportional method. For statistical tests and data processing is done usingPartial Least Square(SmartPLS). The results of this study indicate that: 1) leadership style has a positive and significant effect on job satisfaction, 2) job training has a positive and significant effect on job satisfaction, 3) leadership style has a positive and significant effect on employee performance, 4) job training has a not significant positive effect on employee performance, 5) job satisfaction has a positive and significant effect on employee performance, 6) job satisfaction is able to mediate the effect of leadership style on employee performance, 7) job satisfaction is able to mediate the effect of job training on employee performance. The results of the fit model test showed an NFI value of 0.690 so that it could be said that this research model was 69.0% fit. The test results of the coefficient of determination (R2) shows that the effect of leadership style, job training, and job satisfaction on employee performance is 57.0%.