This study aims to determine and analyze the effect of workload, cyberloafing and self-efficacy on employee performance at Rumah Sakit Islam Purwokerto. The population of this research is the staff of Purwokerto Islamic Hospital. This study applies a quantitative approach method. The sample used in this study amounted to 153 respondents obtained using non-probability sampling with purposive sampling technique. The instrument used in data collection is a questionnaire with primary data measurements. The data obtained was processed using classical assumptions, hypotheses and multiple linear regression analysis with the statistical package for the social sciences (SPSS) analysis tool. The results of this study indicate that workload and self- efficacy have a positive and significant effect on employee performance and cyberloafing has a negative and significant effect on employee performance. Based on the test results of the adjusted R2 coefficient of determination of 83.9%.