This study aims to determine the development of learning media in the form of practicum videos and to obtain appropriate practicum video learning media. This development research uses the stages of RD (Research and Development) with a 4-D model, namely Define, Design, Develop, and Disseminate. The instruments used are in the form of assessment sheets or learning media assessment questionnaires for material experts, media experts, educational practitioners, and students. The data obtained were then analyzed using a qualitative description. The results showed that: (1) The average percentage of practicum video feasibility obtained was 83% with details of material expert validators at 79%, media expert validators at 78%, and practitioner validators at 93%, this means that practicum videos can be used with very decent category, (2) The percentage obtained from student responses is 80% with good category. the results of the study can be concluded that the development of practicum video as a learning medium on cell metabolism material for a twelfth grade can be used in a very feasible category.