The purpose of this study was to examine the effect of religiosity, service quality, knowledge and profit sharing on interest in saving at Islamic banks in Cilacap Regency. The sample selection in this study used purposive sampling. Based on the criteria, 125 respondents were obtained as samples. The data analysis techniques used in this research are descriptive statistical analysis, data instrument test, classical assumption test, multiple linear regression analysis, hypothesis testing. The results of the analysis show that religiosity does not have a positive effect on interest in saving, service quality has a positive effect on interest in saving, knowledge does not have a positive effect on interest in saving and profit sharing has a positive effect on interest in saving.