The existence of different perceptions between generic and branded drugs that exist among the public has been shown by several studies. Poor public perception of generic drugs, need public education about the difference between generic and branded drugs. CBIA proved successful in increasing the value of knowledge and behavior about self treatment. This study aims to determine the difference of generic and branded drug knowledge among health and non-health students of Muhammadiyah University of Purwokerto. This type of research is quasi experimental research with the design used in the form of one group design with pretest and posttest, using two groups of health and non-health student groups given intervention in the form of education using CBIA method (Active Student Learning Method). In this study the number of respondents in the group of health students as much as 54 people and the group of non-health students as much as 54 people. This research was conducted at Muhammadiyah University Purwokerto with kuota sampling technique. Research data of difference of knowledge level were analyzed using Mann Whitney test to see difference of knowledge increase from difference of pretest result with posttest got result 0,661 (p> 0,05) that there is no significant difference from result of comparison. The results obtained in Wilcoxon test to see the increase of knowledge in the group of health students obtained 0,000 (p <0.005) and the group of non-health students obtained 0,000 (p <0.005). From the result of knowledge improvement it is concluded that CBIA method can increase knowledge, and there is no significant difference from the result of the difference.