A part of the people is not aware that the substance concentration in traditional medicines is beneficial, yet possesses risks related to toxicity, drug interaction, and side effects. Traditional gastrointestinal tract medicines are included as over the counter medicines which give free access to the public. This study was an observational analytic using sample calculation with the Slovin formula. Questionnaires were used as the data collection methods. The study was conducted in the drugstore located at the Sokaraja Sub-district with respondents of the visitor's drugstore, with total respondents of 356. The study result shows 151 (42.4%) high intelligence respondents, 182 (51.1%) moderate intelligence respondents, and 23 (6.5%) low intelligence respondents. As much as 164 (46.1%) respondents had a positive attitude, 182 (51.1%) respondents had a neutral attitude, and 10 (2.8%) respondents had a negative attitude. As much as 147 (41.3%) respondents had a positive behavior, 192 (53.9%) respondents had a neutral behavior, and 17 (4.8%) respondents had a negative behavior. Based on the Chi-square test result, it can be concluded that there is a significant relationship among knowledge, attitude, and behavior of the visitor's drugstore at the Sokaraja Sub-district towards the gastrointestinal tract traditional medicine utilization with a p-value of (0.000) < 0.05. The logistic regression analysis result shows that knowledge is the most influential variable towards the gastrointestinal tract traditional medicine utilization with a coefficient value of 0.566.