FORMULASI SEDIAAN GEL DARI NANOPARTIKEL EKSTRAK ETANOL DAUN SIRSAK (Anonna muricate L) SEBAGAI ANTI JERAWAT

FIRDAUS, ANITA (2021) FORMULASI SEDIAAN GEL DARI NANOPARTIKEL EKSTRAK ETANOL DAUN SIRSAK (Anonna muricate L) SEBAGAI ANTI JERAWAT. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Acne is caused by increase of sebum production, decayed keratinocytes, and inflammation that is generally triggered by bacteria such as Propionibacterium acnes. Soursop leaves contain glycosides, alkaloids, saponins, flavonoids, tannins, phenolic compounds, phytosterols and amino acids. Flavonoids, saponins, tannins, terpenoids and alkaloids have been recognized as antibacterial potential. To improve its effectiveness, nanoparticle gel preparations for ethanol extract of soursop leaves were made. This study was that conducted to determine the activity of the nanoparticle gel preparation of the ethanol extract of soursop leaves as an antibacterial on bacteria P.acnes. The formulation was considered stable according to the accelerated stability test for 28 days storage were include organolepticobservation, dispersionability, pH, and viscosity. Evaluation antibacterial activity gel of nanoparticles ethanol extract soursop leaves concentration 5%, 10%, 15%, against Propionibacterium acne by using agar diffusion method with paper disc. Test results showed that the gel preparation that had good antibacterial activity was a gel containing ethanol extract nanoparticles of soursop leaves at a concentration of 15% against P. acnes. So that the nanoparticle gel formula of ethanol extract of soursop leaves has the potential as an anti-drug acne.

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