The purpose of this study was to analyze the effect of price earning ratio, book value per share, debt to asset ratio, inflation and Indonesian interest rates on stock price volatility with profitability as a control variable. This study was conducted on the LQ45 index companies listed on the Indonesia Stock Exchange during 2017-2019. Data obtained from the official website of the Indonesia Stock Exchange. The data used in this research includes data on financial statements of LQ45 index companies listed on the Indonesia Stock Exchange (IDX). This study used a purposive sampling method using 47 sample companies with several predetermined criteria. Data were analyzed using descriptive analysis, multiple regression analysis and classical assumption test. The results revealed that the price earning ratio has a negative and insignificant effect on stock price volatility. Book value per share has a negative and significant effect on stock price volatility. Debt to asset ratio has a negative and insignificant effect on stock price volatility. Inflation has a negative and significant effect on stock price volatility. And Indonesian interest rates have a negative and significant effect on stock price volatility.