Cancer is one of the leading causes of death in the world. Breast cancer is the
most common cancer in Indonesia. Cancer therapy that is often used is surgery, radiation,
and chemotherapy, but this therapy still has shortcomings. PDT is a relatively safer
cancer therapy. PDT has three main components namely the light source, photosensitizer,
and oxygen. One of the photosensitizers currently being developed is the Zinc
Phthalocyanine (ZnPc) compound. ZnPc is a derivative of phthalocyanine compound
which has a macrocyclic tetrapirol structure with zinc metal content. The aim of this
research to find out the potential of ZnPc compounds as photosensitizers in PDT. The
cytotoxic tests with MTT were carried out while without radiation and PDT activity tests
with irradiation with an incubation time of 24 hours and 48 hours on T47D breast cancer
cells. The results of cytotoxic tests without irradiation obtained IC50 values = 4.167 x 106
μM which showed that ZnPc did not cause significant inhibition of T47D cell growth.
Whereas the PDT activity test obtained IC50 value = 8.997 μM in 24 hours incubation
time and IC50 = 7.375 μM in 48 hours incubation. ZnPc has the potential as a
photosensitizer in PDT because it has a strong toxic effect on T47D breast cancer cells.