AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI BATANG SEREH (Cymbopogon citratus (DC.) Stapf) TERHADAP BAKTERI Streptococcus mutans

YUNISA, NAZILA (2013) AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI BATANG SEREH (Cymbopogon citratus (DC.) Stapf) TERHADAP BAKTERI Streptococcus mutans. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

NAZILA YUNISA. Antibacterial Activity Of Lemongrass (Cymbopogon citratus (DC.) Stapf) Stem Extracts And Fraction Against Streptococcus mutans. Under the guidance TJIPTASURASA and RETNO WAHYUNINGRUM Background: The biggest problem faced by residents of Indonesia as well as in other developing countries in the field of dental and oral diseases are dental hard tissue (caries dentine). One of the dominant bacterial species in the mouth are Streptococcus mutans. Stem of lemongrass (Cymbopogon citratus (DC.) Stapf) is a plant that has antibacterial activity. Secondary metabolites found in the lemongrass expected to provide antibacterial activity against S.mutans. Objective: This study aimed to compare the effect of ethanolic extract and varying the concentration of the fraction of the ethanol extract of the lemongrass stem against growth of S.mutans. Methods: Extraction of lemongrass stems made by maceration method using 70% ethanol, followed by liquid-liquid fractionation process with n-hexane, ethyl acetate and methanol solvents that can represent non-polar, semi-polar and polar solvents. Extracts and fractions obtained tested antibacterial activity using gelatine diffusion method with streptomycin as positive control and DMSO as a negative control. Result: The ethanol extract of lemongrass stems at a 10% concentration gave inhibition zone of 23,96 mm. N-hexane fraction gave inhibition zone at concentrations of 10% and 100% at 8,71 mm and 18,27 mm, while the fraction of ethyl acetate and methanol fractions alike inhibition zone at a concentration of 100% amounting to 10,94 mm and 16,40 mm. Conclusion: Extract of lemongrass (Cymbopogon citratus (DC.) Stapf) stems at a concentration of 10% has antibacterial activity against S.mutans. Fraction of n-hexane, ethyl acetate and methanol also has antibacterial activity against S.mutans, but smaller than the antibacterial activity of ethanol extract of the lemongrass stems.

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