Curcuminoid gel formulation has been studied as antiacne and antibacterial
activity againt Staphylococcus aureus. The purpose of this research was to create
a gel formula and test the physical characteristic of curcuminoid and antibacterial
activity against Staphylococcus aureus. This study used four formula with two
bases of CMC Na and Carbopol. The first and second formula as a negatif control
containing only the base of CMC Na and Carbopol base, third contains the base of
CMC Na and the active substance of Curcuminoid, and fourth formula contains of
Carbopol base and the active substance of Curcuminoid. The positif control using
Clindamycin gel l%. Gel was tested physical characteristic including:
Organoleptic, pH, and Viscosity. The study of antibacterial activity was done by
diffusion method. Viscosity data was analyzed using two-ways of ANAVA with
95% of confidence level. While for antibacterial activity data was analyzed using
one-ways ANAVA with 95% of believable level. The result showed that
curcuminoid gel didn’t has an antibacterial activity, so that the test was done on
the antibacterial activity against tumeric extract for about 7%. The result showed
that gel on the base of CMC Na had a great power to inhibit Staphylococcus
aureus.