TINGKAT KEBERHASILAN KEMOTERAPI BERBASIS DOXORUBICIN PADA PASIEN KANKER PAYUDARA DI RSUD Prof. Dr. MARGONO SOEKARJO TAHUN 2008-2012

SYARIFAH, ARINI (2013) TINGKAT KEBERHASILAN KEMOTERAPI BERBASIS DOXORUBICIN PADA PASIEN KANKER PAYUDARA DI RSUD Prof. Dr. MARGONO SOEKARJO TAHUN 2008-2012. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Research background : Cancer has become the second causes mortality after cardiovascular, and it is breast cancer which is most common happen to women. One of the recommended chemotherapy agent by National Comprehensive Cancer Network (NCCN) as the first line breast cancer therapy either combination or single is doxorubicin. However, doxorubicin has side effects and it is not spesific to cancer cell, so it tends to cause a breast cancer cell-resistence to medicine. As the result, the breast cancer therapy will be failed. . Research Aims :This research was aimed to know the successfull rate of doxorubicin-based chemotherpy, that was CAF and PEC, to the breast cancer patients at RSUD Prof. Dr. Margono Soekarjo Purwokerto through the precentage parameter of recurence and the precentage of overall survival. Research Method : This research was observational research which used analytical method. The research design was cross sectional. Analytical with retrospective approach was used as the observation or data collection method. Research Findings : From 82 patients, 41 (50%) patients received CAF chemotherapy and 41 (50%) patients received PEC chemotherapy. The average age of the patients who received CAF and PEC chemotherapy were 53,09+ - 10,32 years old. The visit findings showed that there was a recurence significant difference between CAF group and PEC group. In CAF group, the recurence result was 46,9% and in PEC group it was 53,7%. The one year overall survival which was gotten by CAF group was 61,0% and PEC group was 43,9%. The group which gave the low recurence was PEC group, while the group which gave good overall survival was CAF group. Conclusion: From the recurence precentage and one year overall survival, it can be concluded that the use of doxorubicin-based chemotherapy is not effective.

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