Metformin hydrochloride is the class of biguanida medicine to cure type 2
Diabetes Mellitus. The main absorption of Metformin is on the proxymal of
intestinal. Floating tablet is one of gastroretentive dosage form that uses lowdensity
system, has more floating duration and stays in the stomach althought in
discharging period. So that way can increase gastric residence time (GRT) and
bioavailability of Metformin HCl medicine. The aim of research was to identify
the impact of Polygel CA and ethylcellulose toward physical characteristic of
tablet, floating character and profile dissolution floating tablet Metformin HCl.
The making of tablets was by wet granulation method. Formula determining was
done by using simplex lattice design method that was supported by software
Design-Expert 7.0.0. Comparison of Polygel CA and Ethyl cellulose for Run 1
((93,750 mg : 93,750 mg), Run 2 (0,000 mg : 187,500 mg), Run 3 (140,625 mg :
46,875 mg), Run 4 (46,875 mg : 140,625 mg), dan Run 5 (187,500 mg : 0,000
mg). The test were: granule’s flowing characteristic, weight similarity, solidity,
fragility, dissolved time, floating character, amount determination and dissolution.
The result showed that the increasing Polygel CA could increase flowing velocity
respone, tablet solidity, decreasing floating lag time, and decreasing floating
duration. More ethylcellulose could increase flowing velocity response, tablet
solidity, dissolution time, decreasing fragility, increasing floating lag time, and
increasing floating duration. Releasing kineic Run 1, 3, and 5 follow first order,
Run 2 and 4 with kinethic zero-order and one have domination first-order.
Releasing mechanism Run 1, 3 and 5 has dominant control by diffusion, Run 2
and 4 are controlled by diffuse mechanishm and erosion, which is more dominant
diffuse mechanism.