MUKHAROMAH, MA’RIFATUN (2017) VALIDASI METODE ANALISIS PROPRANOLOL DALAM PLASMA MANUSIA IN VITRO SECARA KROMATOGRAFI LAPIS TIPIS DENSITOMETRI. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Propranolol is an effective beta-blocker drug against hypertensive disease.
Propranolol HCl is first past metabolism in liver by CYP2C19 and 2D6 in oral
administration. Measurement of plasma drug levels can provide information on drug
about drug presents in tissues and the possible pharmacological or toxicological
effects of a drug dosage and the formation or drug transport metabolites. Validation
method of analysis propranolol in human plasma in vitro by thin layer
chromatography densitometry, using stationary phase silica gel F 254 and mobile
phase consisted of chloroform: methanol: ammonia (9:1:0.2 v/v ).Validation methods
of analysis include the linearity, limit of detection (LOD),limit of quantity (LOQ),the
precision and the accuracy.
The results were show value of linearity with coefficient correlation or r value
= 0.9739(> r table = 0.878), the limit of detection (LOD) value was = 0.669 μg, the
limit of quantity (LOQ) value = 2.230 μg, the precision concentration value to
propranolol 3.52 μg was RSD = 8.89% (5-15%), the accuracy of recoveries amount
3.52 μg the average of recovery = 92.03% (80-120%) .The analysis results were
show that the method of propranolol analysis in human plasma in vitro by Thin layer
chromatography - densitometry is valid.

Dosen Pembimbing: unspecified | unspecified
Item Type: Thesis (Bachelor)
Additional Information: Pembimbing: Dr.Pri Iswati Utami, M.sc.,Apt dan Elza Sundhani, M. Sc., Apt
Uncontrolled Keywords: TLC-Densitometry, Propranolol, Human Plasma
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi S1
Depositing User: Dan Kh
Date Deposited: 22 Sep 2017 01:36
Last Modified: 13 Nov 2024 03:18
URI: http://repository.ump.ac.id/id/eprint/4317

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