This research aimed to analyze financial ratios Return on Asset (ROA), Return on Equity (ROE), Operational Efficiency Ratio (BOPO), Capital Adequacy Ratio (CAR), Non Performing Financing (NPF), Financing Deposito Ratio (FDR), on Change in Profit. The objects of this research were Sharia General Banks that Go Public in Indonesia. This research used 11 samples of sharia general banks that met the criteria. Data collection technique used in this research was purposive sampling method and the data were analyzed using descriptive statistic, classical assumption test, multiple regression analysis, and hypothesis testing. The result of the analysis showed that Return on Asset (ROA), Return on Equity (ROE), Operational Efficiency Ratio (BOPO), Capital Adequacy Ratio (CAR), Non-Performing Financing (NPF), Financing Deposito Ratio (FDR) simultaneously had effect on the change in profit of sharia banks in Indonesia. Meanwhile, partially ROA had positive and significant effect toward the change in profit. ROE had negative and insignificant effect. Operational Efficiency Ratio (BOPO) had negative and significant effect on change in profit. Capital Adequacy Ratio (CAR) had negative and insignificant effect on the change in profit. Non-Performing Financing (NPF) had positive and significant effect on the change in profit. Financing Deposito Ratio (FDR) had negative and insignificant effect on the change in profit.