Tetrahydrocurumumine (THC) has antiinflammatory activity but low water solubility
has an effect on bioavailability value. Tetrahydrocurumumin made in the Selfnanoemusifying
Drug Delivery System (SNEDDS) is expected to improve
bioavailability. The purpose of this research is to get optimum formula of SNEDDS
using d-Optimal design. As the independent variable is the amount of oil, surfactant
and cosurfactant. As the dependent variable is emulsification time, percent
transmittance and DE15. The optimum formula of SNEDDS consisted of 10%
labrafil, 80% colifor: labraol 25%: 75% and 10% PEG 400. DE15 optimum formula
49.45%, significantly higher than THC before modified. The estimated value of the
response did not differ significantly with the response value of the experimental
results. The optimum formula of SNEDDS THC from Design Expert 7.0 (DX 7.0) has
a nanometer particle size of 53.8 nm. The level of uniformity of particle distribution
is well characterized by the value of Polydispersity Index (PI) 0.043 while the
potential zeta value -19.4 mV means less good.