The aim of this research was to find out the effectiveness of Pictionary game for teaching vocabulary at the First Grade Students of SMP Muhammadiyah 1 Purbalingga in Academic Year 2015/2016.This research was conducted by using quasi experiment research. The participants of this research were the first grade students of SMP Muhammadiyah 1 Purbalingga. There were two classes which class A as the experiment group and class B as the control group consisted of 33 students of each class. In collecting the data, this research used test. It was pre-test and post-test. The test consisted of multiple choice items and matching test items. Based on the computation, t-test result was 2.68 and value of t-table at the significant level 0,05 with the degree of freedom was the 1.669. Thus, (2.68 > 1.669) and it showed that the hypothesis was accepted of using Pictionary game. It is showed that Pictionary game was effective for teaching vocabulary at the First Grade Students of SMP Muhammadiyah 1 Purbalingga in Academic Year 2015/2016.