Background : Pain is an uncomfortable feeling caused by sensory stimulation and
emotional feelings , which is related to tissue damage. Analgesic is drug group
peripherals that can used for overcome pain. Drug Analgesics can cause side effects
ie intestinal and stomach disorders, etc. So it is necessary to innovate other forms of
analgesic dosage forms that have a better level of safety. The bitter plant is known to
contain androgafolid compounds which can inhibit the synthesis of endogenous
substances that can stimulate pain nerve endings. The bitter extract patch and
cream have been formulated with a dose of 500 mg/kg on test animals, but a
comparative test of the analgesic activity of each preparation has not been carried
out. This test aims to determine which dosage form has the highest analgesic
activity on mice. Method : The effectiveness of analgesic patches and creams can
be seen from the increase in the % of analgesic power which is indicated by a
decrease in the number of writhing through the writhing test method, observations
carried out every 5 minutes for a period of 60 minutes. Results : the % analgesic
power value in the negatif group was 0%, in the patch base group showed a value
of 15.20%, the cream base group showed a value of 2.24%, in the patch test group
showed a result of 65.21%, and in The test group obtained a value of 51.29%.
Conclusion : The dosage form that produced the highest analgesic activity in
BALB/C strain mice was a patch of bitter extract at a dose of 500 mg/kg BW of
the test animals, with a marked increase in the % value of analgesic power.