Background: SARS-CoV-2 was first reported in those identified as betacoronavirus having the ability to transmit via aerosols and fomites with a total of 765,222,932 cases and 6,921,614 deaths which have been reported in 180 countries and regions. Resistance in SARS-CoV-2 to drugs continues to develop so that the development of current anti-covid drugs continues. This is the background for conducting in silico studies to develop the potential of active compounds in herbal plants. Methods: kikkanol E and Z-3-(2,4,5-trimethoxyphenyl)-2-propenal compounds from herbal plants that have potential against SARS-CoV-2 were measured by the binding energy value, molecular binding was carried out on 7 mutant proteins from 3CLpro PDB ID: 6M2N using AutoDockTools software, then the results will be compared with the binding affinity value of the 3CLpro wild type protein. Results: The results of the molecular docking showed that the 3CLpro mutant from SARS-CoV-2 experienced a significant increase in binding energy. The highest increase in the 3CLpro mutant with kikkanol E was found in mutant number 266. Meanwhile, in the 3CLpro mutant with Z-3-(2,4,5-trimethoxyphenyl)-2-propenal it was in mutant number 220 and decreased binding energy in mutant number 75 The visualization results showed that the 3CLpro mutant underwent a change in interaction when compared with the wild type protein of 3CLpro. Conclusion: the affinity of kikkanol E and Z-3-(2,4,5-trimethoxyphenyl)-2-propenal for 3CLpro has changed a lot, marked by a significant increase in binding energy value and a decrease in binding energy seen in Z-3-(2) ,4,5-trimethoxyphenyl)-2-propenal against mutant number 75 3CLpro compared to the natural 3WL ligand of 3CLpro 6M2N resulting in many changes in the interaction between the ligand and the mutant protein