ANALISIS BAHAN KIMIA OBAT PARASETAMOL DALAM JAMU SAKIT GIGI YANG BEREDAR DI CILACAP DENGAN METODE KLTDENSITOMETRI

ARIYANTI, SIFA JUNI (2023) ANALISIS BAHAN KIMIA OBAT PARASETAMOL DALAM JAMU SAKIT GIGI YANG BEREDAR DI CILACAP DENGAN METODE KLTDENSITOMETRI. S1 thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Background: Public warning published by the Food and Drug Supervisory Agency (BPOM) Number PW.02.04.1.4.10.22.166 of 2022 states that 41 traditional medicines have been found containing chemical drug ingredients. One of them is toothache herbal medicine containing chemical drug ingredients of paracetamol. This study aims to identify and determine the levels of paracetamol drug chemicals and obtain valid methods to be used in analyzing paracetamol content in toothache herbal preparations circulating in Cilacap. Method: The method used to analyze paracetamol content in 4 samples of toothache herbs obtained directly from the herbal medicine depot in Cilacap is TLC-Densitometry, using stationary phase silica gel F254 and mobile phase chloroform: ethanol (8: 1). Spotting detection is carried out by densitometry in a wavelength of 250 nm. Results: The results of the method validation obtained are the value of the correlation coefficient (r) = 0.996, LOD = 0.0005%, LOQ = 0.0017%. The precision test is shown by the RSD value (1.127%), and the accuracy obtained is 98.817%. Conclusion: The validation results of the paracetamol analysis method in toothache herbs using the TLC-Densitometry method have met the parameters of linearity, LOD, LOQ, precision, and good accuracy, it can be said that this method can be used to determine levels in samples of toothache herbs circulating in Cilacap. Of the 4 herbal medicine samples, 3 samples (w, x, and y) were positive for paracetamol with each level of 2.6% (w/w); 12.7% (w/w); and 10.9% (w/w).

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