The growth and development of MSMEs in the digital era is very rapid, this also increases the use of accounting information systems. This study aims to analyzea accounting knowledge, business experience and education level on the use of accounting information systems in MSME actors. The population in this study is all UMKM actors in Banyumas district. The sampling technique and method to be used is a non probability sampling technique. This technique is a sampling technique that does not provide equal opportunities or opportunities for every element or member of the population to be selected into the sample. The analytical tool in this study uses the Structural Equation Model Partial Least Square (SEMPLS). The results of this study show that accounting knowledge variables have a positive effect on the use of accounting information systems. Business experience variables positively affect the use of accounting information systems. The variable level of education does not have a positive effect on the use of accounting information.