The purpose of this study was to determine the effect of profit sharing financing, buying and selling financing, financing to deposit ratio, non-performing financing and sharia supervisory board meetings on profitability in Islamic commercial banks in Indonesia. This study uses a quantitative approach. The population of this study is Islamic Commercial Banks registered with the Financial Services Authority (OJK) in 2017-2021. The sampling technique used was purposive sampling with 14 companies and 42 samples were obtained that met the criteria. The data analysis technique used is multiple regression analysis with the SPSS program. Profitability in this study is measured using Return On Assets (ROA). Based on the results of the study, it can be concluded that the profit sharing financing variable has a negative effect on profitability, buying and selling financing has a positive effect on profitability, financing to deposit ratio has a negative effect on profitability, while non-performing financing and sharia supervisory board meetings have no effect on profitability.