Background: Ischemic stroke that occurs in the elderly can worsen the patient's condition which is characterized by a decrease in sensory, motor and cognitive function caused by damage to brain cells. Stroke is included in cerebrovascular disease in which there are functional abnormalities in the brain's nervous system that experience a spontaneous decline in 24 hours caused by impaired blood circulation to the brain. One of the management of ischemic stroke is administration of neuroprotectant drugs. The neuroprotectant drug used in Majenang Hospital uses citicoline. Irrational use of neuroprotectant drugs can cause death. Based on this description, it is necessary to evaluate the use of ischemic stroke neuroprotectant drugs in the elderly so that patients get the right, safe and effective drugs for patients. Methods: This research was conducted in a descriptive non-experimental observational manner with retrospective data collection. The number of samples used were 42 patients. Analysis of the results is presented in the form of tables and percentages. Results: The pattern of use of neuroprotectant drugs found the number of citicoline used in 42 patients (100%). The rationality of using neuroprotectant drugs obtained is 100% right indication, 100% right patient, 100% right drug, 100% right dose and 100% right route of administration. Conclusion: The use of neuroprotectant drugs given to elderly ischemic stroke patients is rational. The effectiveness of the therapy in elderly ischemic stroke is 67.67% effective and the ineffectiveness was 33.33%.