The purpose of this study was to determine the effect of Independent Attitude, Self-Efficacy and Family Environment on Interest in Entrepreneurship. The sample selection in this study used purposive sampling. Based on the criteria, 120 respondents were obtained as samples. The data analysis techniques used in this research are descriptive statistical analysis, data instrument test, classical assumption test, multiple linear regression analysis, hypothesis testing, and model fit test. The results of the analysis show that independent attitudes, self-efficacy and family environment simultaneously affect interest in entrepreneurship, independent attitudes have no significant positive effect on interest in entrepreneurship, self-efficacy has a significant positive effect on interest in entrepreneurship, family environment does not have a significant positive effect on interest in entrepreneurship.