This study aims to determine the student's interest in entrepreneurship, the student's product innovation ability, and the relationship between the interest in entrepreneurship and the student's product innovation ability. This type of research was descriptive quantitative research with a survey method. Questionnaires and interviews wereused to collect data. The data obtained were then analyzed by calculating the total score of the questionnaireusing the percentage and Pearson correlation techniques. The results showed that: (1) student entrepreneurshipinterest in the biology education study program for the academic year of 2021-2022 was included in the very highcategory with a score of 81%, and (2) product innovation ability in the biology education study program for theacademic year 2021-2022 is included in the high category with a score of 76%, and 3) there is a relationshipbetween interest in entrepreneurship and product innovation ability, but the relationship is included in the lowcategory with a Pearson correlation value of 0.264.