Basically, GIS can be broken down into several interrelated sub-systems which include data input, data management, data processing or analysis, reporting (output) and analysis results. The components that make up a GIS are software, hardware, data, users, and applications. GIS technology integrates database-based data processing operations that are commonly used today, such as data retrieval based on needs, as well as statistical analysis using distinctive visualizations and the various advantages that geographic analysis can offer through its map images. Creating a geographic information system application for the spread of diarrhea disease in Purbalingga Regency makes it easier for the public to see the spread of diarrhea and how to deal with this diarrhea disease. With the application of information on the spread of diarrheal diseases based on this android, you can easily see areas where the spread of diarrhea is low to high and this information application can improve the quality of data collection on the spread of diarrhea in the Purbalingga Regency area.