This study aims to examine effect the Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR), Operational Costs per Operating Income (BOPO), Non Performing Financing (NPF) against Return on Assets (ROA). The population in this study is a Sharia Commercial Bank registered with the Financial Services Authority (FSA) in 2015-2018, namely 14 Sharia Commercial Banks. The sample selection in this study was conducted by purposive sampling. The analysis technique used in this study is multiple linear regression. The results of this study indicate that the Capital Adequacy Ratio (CAR) and Operating Costs per Operating Income (BOPO) has a significant negative effect on Return On Assets (ROA). Financing to Deposit Ratio (FDR) has a significant positive effect on Return On Assets (ROA). while Non Performing Financing (NPF) has no significant negative effect on Return On Assets (ROA).