UJI AKTIVITAS ANTIKANKER MANGANESE (II) PHTHALOCYANINE TERHADAP SEL KANKER PAYUDARA T47D SECARA PHOTODYNAMIC THERAPY

AVERROES, FOVEA WINDHIA BONDAN (2020) UJI AKTIVITAS ANTIKANKER MANGANESE (II) PHTHALOCYANINE TERHADAP SEL KANKER PAYUDARA T47D SECARA PHOTODYNAMIC THERAPY. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Cancer is one of the leading causes of death in the world. Breast cancer is the most common cancer in Indonesia. Cancer therapy that is often used is surgery, radiation, and chemotherapy, but this therapy still has shortcomings. PDT is a relatively safer cancer therapy. PDT has three main components namely the light source, photosensitizer, and oxygen. One of the photosensitizers currently being developed is the Manganese (II) Phthalocyanine (MnPc) compound. MnPc is a derivative of phthalocyanine compound which has a macrocyclic tetrapirol structure with manganese metal content. The aim of this research to find out the potential of ZnPc compounds as photosensitizers in PDT. Method:The cytotoxic tests with MTT were carried out while without radiation and PDT activity tests with irradiation with an incubation time of 24 hours and 48 hours on T47D breast cancer cells. Results: The cytotoxic tests without irradiation obtained IC50 values = 40.285 μM ± 1,77 which showed that MnPc did not cause significant inhibition of T47D cell growth. Where as the PDT activity test obtained IC50 value = 9.888 μM ± 0,72 in 24 hours incubation time and IC50 = 6,21 μM ± 0,82 in 48 hours incubation. MnPc has the potential as a photosensitizer in PDT because it has a strong toxic effect on T47D breast cancer cells.

Item Type: Thesis (Bachelor)
Uncontrolled Keywords: PDT, manganese (II) phthalocyanine, cancer, T47D.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Farmasi S1
Depositing User: Agus Imam
Date Deposited: 26 Jul 2022 05:50
Last Modified: 26 Jul 2022 05:50
URI: https://repository.ump.ac.id:80/id/eprint/12930

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