KARAKTERISTIK FISIKOKIMIA SENYAWA PHTHALOCYANINE UNTUK TERAPI KANKER SECARA FOTODINAMIK

ASRIANI, AUDI (2019) KARAKTERISTIK FISIKOKIMIA SENYAWA PHTHALOCYANINE UNTUK TERAPI KANKER SECARA FOTODINAMIK. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Cancer is the one of the leading causes of death in the world. The one of cancer treatment is Photodynamic Therapy (PDT). Photodynamic therapy is a cancer therapy using photosensitizers which are injected into the body then illuminated with light at certain wavelengths so as to produce singlet oxygen which can kill cancer cells by necrosis. Photodynamic therapy is more promising than other cancer therapies because of its selectivity to cancer cells. One of the photosensitizer compound used in photodynamic therapy is phthalocyanine. The type of this research is a nonexperimental method. The result of the partition coefficient value of phthalocyanine is 5.70 indicating that phthalocyanine have high lipophilicity so that they easily penetrate cell membranes. The results of the molar absorptivity (ε) of phthalocyanine were 1416 cm-1 M-1 in the Q1 band 693 nm so that phthalocyanine could be used in small doses. From the results of measuring singlet oxygen quantum values (ΦΔ) phthalocyanine have a value of ΦΔ greater at pH 7,4 (ΦΔ= 0,28) compared to pH 6,3 (ΦΔ= 0,26) so that it has the potential for photodynamic therapy. From the results of the measurement of the quantum yield fluorescence (ΦF) phthalocyanine has a ΦF value 0.0214 so that it has the potential for cancer photodiagnostics. From the results of the stability test on indirect sunlight the phthalocyanine is not stable against sunlight as evidenced by an absorption decrease of 8.47%.

Item Type: Thesis (Bachelor)
Uncontrolled Keywords: cancer, photodynamic therapy, phthalocyanine, quantum yield singlet oxygen, quantum yield fluorescence
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Farmasi > Farmasi S1
Depositing User: Danarto Kh
Date Deposited: 20 Jun 2022 04:25
Last Modified: 20 Jun 2022 04:25
URI: http://repository.ump.ac.id/id/eprint/12030

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