The purpose of this study was to determine the effect of the board of commissioners, sharia supervisory board, financing to deposit ratio, and company size on profitability proxied by ROA (Return On Assets) in Islamic commercial banks listed in the Financial Services Authority in the 2014-2018 period. The sampling technique used was purposive sampling technique in order to obtain a sample of 14 companies with 70 data processed. The data analysis technique used is multiple linear regression analysis with the help of the SPSS program. The results of this study indicate that the variable board of commissioners, sharia supervisory board, and financing to deposit ratio does not affect profitability. However, another variable, namely company size, has a positive effect on profitability.