OPTIMASI FORMULA KRIM MINYAK ATSIRI BUAH ADAS (Foeniculum vulgare, Mill) SEBAGAI ANTIJERAWAT

PRIAMA, FITRA YUDHA (2019) OPTIMASI FORMULA KRIM MINYAK ATSIRI BUAH ADAS (Foeniculum vulgare, Mill) SEBAGAI ANTIJERAWAT. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

Acne is a skin disorder which is caused by the bacterium Propionibacterium Acne. One of the subtances that can be benefited as an antibacterial agents is essential fennel oil (Foeniculum vulgare, Mill). The purpose of this study were to determine the optimum composition of cera alba and stearic acid in essential fennel oil cream, and to get the optimum formula of essential fennel oil which has antibacterial activity. This research was an experimental study using D-Optimal Mixture Design method where cera alba and stearic acid are formulated into o/w cream in 9 compositions and seen by response of viscosity test, spread ability test, and pH test using Design Expert® 7.1.5 and continued with the test T-Test with 95% confidence level for formula verification. While the antibacterial activity test in the form of inhibition zones were analyzed by One Way Anova. The results obtained are the optimum formula has a desirability value of , with a composition of cera alba 8 grams and stearic acid 10 grams. Cera alba has an effect on increasing the response of spread ability and pH, and on the viscosity response of stearic acid is more influential. The results of verification of the optimum formula showed the experimental value and the predicted value was not significantly different (p <0.05). One Way Anova results showed a significant difference in negative control, positive control and fennel essential oil cream formula on the growth of p.acne bacteria (p <0.05).

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	fennel essential oil, test response, optimum formula, antibacterial activity
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Farmasi S1
Depositing User:	Dan Kh
Date Deposited:	07 Jun 2022 06:58
Last Modified:	07 Jun 2022 06:58
URI:	https://repository.ump.ac.id:80/id/eprint/11857

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