KARAKTERISTIK FISIKOKIMIA SENYAWA MANGANESE(II) PHTHALOCYANINE UNTUK TERAPI KANKER SECARA FOTODINAMIK

PRASETYONINGSIH, TALITHA LATIFAH (2019) KARAKTERISTIK FISIKOKIMIA SENYAWA MANGANESE(II) PHTHALOCYANINE UNTUK TERAPI KANKER SECARA FOTODINAMIK. Bachelor thesis, UNIVERSITAS MUHAMMADIYAH PURWOKERTO.

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Abstract

The number of deaths caused by cancer continues to grow. However, cancer therapies that are generally carried out include surgery, radiotherapy, and chemotherapy, still have shortcomings. Photodynamic therapy (PDT) is a cancer therapy that is currently being developed. PDT is a therapy by combining components in the form of photosensitizer, light, and oxygen, which are only localized to cancer cells. The used compound is a model of the photosensitizer derivative of metallated phthalocyanine compound which has a macrocyclic tetrapyrrole structure, namely Manganese(II) Phthalocyanine (Mn(II)Pc). This study aims to determine the physicochemical characteristics of the Mn(II)Pc compound which determine its potential in PDT. The research method carried out in the form of non-experimental. The absorption prediction result of the value of log P = 4,85 indicate the compound Mn(II)Pc is lipophilic. The measurement 100 cm-1 M-1 indicate that the compound Mn(II)Pc can be used in low concentrations for cancer therapy in deeper tissues. The Mn(II)Pc compound can produce singlet oxygen quantum yields ( ) at pH 6,3 and 7,4 with a value of 0,14. The result of quantum F) is 0,01. Based on, the stability test for indirect sunlight showed that the compound Mn(II)Pc underwent photodegradation for 3,5 hours of measurement. It can be concluded that the compound Mn(II)Pc has the potential to be used in PDT, but not has potential for photodiagnostic.

Item Type: Thesis (Bachelor)
Uncontrolled Keywords: Cancer, Photodynamic Therapy, Manganese(II) Phthalocyanine
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Farmasi > Farmasi S1
Depositing User: Danarto Kh
Date Deposited: 30 May 2022 05:50
Last Modified: 30 May 2022 05:50
URI: https://repository.ump.ac.id:80/id/eprint/11725

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